Topical tacrolimus therapy of resistant cutaneous lesions in lupus erythematosus: a possible alternative
Identifieur interne : 001F38 ( Main/Exploration ); précédent : 001F37; suivant : 001F39Topical tacrolimus therapy of resistant cutaneous lesions in lupus erythematosus: a possible alternative
Auteurs : C. E. Lampropoulos [Royaume-Uni] ; S. Sangle [Royaume-Uni] ; P. Harrison [Royaume-Uni] ; G. R. V. Hughes [Royaume-Uni] ; D. P. D'Cruz [Royaume-Uni]Source :
- Rheumatology [ 1462-0324 ] ; 2004.
Abstract
Objective. To determine the efficacy of tacrolimus ointment 0.1% on resistant cutaneous lesions in patients with lupus erythematosus. Methods. Twelve patients with skin manifestations were studied. Six had discoid lupus (DL), four subacute cutaneous lupus erythematosus (SCLE) and two systemic lupus erythematosus (SLE). All patients had extensive skin lesions refractory to previous treatment. Patients received topical tacrolimus 0.1% for a minimum of 6 weeks and response was evaluated by physicians’ and patients’ assessment and documented with photographs at baseline and at the end of the treatment. Results. Eleven of 12 patients completed the therapy. One patient with DL discontinued because of side-effects—peeling and a burning sensation. Six patients were clearly improved, one patient had a minor remission of his face lesion while in four the rashes remained the same. Two patients with SCLE had significant regression of their lesions while the other two had no improvement. In DL, two had certain improvement, one minor improvement and two were without response. The patients with SLE had significant amelioration of their extensive photosensitive rash. Conclusion. Tacrolimus ointment 0.1% may be an effective alternative in patients with severe resistant cutaneous manifestations in lupus erythematosus.
Url:
DOI: 10.1093/rheumatology/keh325
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002C79
- to stream Istex, to step Curation: 002C79
- to stream Istex, to step Checkpoint: 000D79
- to stream Main, to step Merge: 001F53
- to stream Main, to step Curation: 001F38
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Topical tacrolimus therapy of resistant cutaneous lesions in lupus erythematosus: a possible alternative</title><author><name sortKey="Lampropoulos, C E" sort="Lampropoulos, C E" uniqKey="Lampropoulos C" first="C. E." last="Lampropoulos">C. E. Lampropoulos</name></author><author><name sortKey="Sangle, S" sort="Sangle, S" uniqKey="Sangle S" first="S." last="Sangle">S. Sangle</name></author><author><name sortKey="Harrison, P" sort="Harrison, P" uniqKey="Harrison P" first="P." last="Harrison">P. Harrison</name></author><author><name sortKey="Hughes, G R V" sort="Hughes, G R V" uniqKey="Hughes G" first="G. R. V." last="Hughes">G. R. V. Hughes</name></author><author><name sortKey="D Cruz, D P" sort="D Cruz, D P" uniqKey="D Cruz D" first="D. P." last="D'Cruz">D. P. D'Cruz</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1F92CFBC5790A24478CCF45C2340510AD4B2C4B2</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1093/rheumatology/keh325</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-B13RX061-9/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002C79</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002C79</idno><idno type="wicri:Area/Istex/Curation">002C79</idno><idno type="wicri:Area/Istex/Checkpoint">000D79</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000D79</idno><idno type="wicri:doubleKey">1462-0324:2004:Lampropoulos C:topical:tacrolimus:therapy</idno><idno type="wicri:Area/Main/Merge">001F53</idno><idno type="wicri:Area/Main/Curation">001F38</idno><idno type="wicri:Area/Main/Exploration">001F38</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Topical tacrolimus therapy of resistant cutaneous lesions in lupus erythematosus: a possible alternative</title><author><name sortKey="Lampropoulos, C E" sort="Lampropoulos, C E" uniqKey="Lampropoulos C" first="C. E." last="Lampropoulos">C. E. Lampropoulos</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sangle, S" sort="Sangle, S" uniqKey="Sangle S" first="S." last="Sangle">S. Sangle</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Harrison, P" sort="Harrison, P" uniqKey="Harrison P" first="P." last="Harrison">P. Harrison</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hughes, G R V" sort="Hughes, G R V" uniqKey="Hughes G" first="G. R. V." last="Hughes">G. R. V. Hughes</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="D Cruz, D P" sort="D Cruz, D P" uniqKey="D Cruz D" first="D. P." last="D'Cruz">D. P. D'Cruz</name><affiliation wicri:level="3"><country xml:lang="fr" wicri:curation="lc">Royaume-Uni</country><wicri:regionArea>Lupus Research Unit, The Rayne Institute, St Thomas’ Hospital, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Rheumatology</title><title level="j" type="abbrev">Rheumatology</title><idno type="ISSN">1462-0324</idno><idno type="eISSN">1462-0332</idno><imprint><publisher>Oxford University Press</publisher><date type="e-published" when="2004-07-20">2004</date><date when="2004-11">2004</date><biblScope unit="vol">43</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1383">1383</biblScope><biblScope unit="page" to="1385">1385</biblScope></imprint><idno type="ISSN">1462-0324</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1462-0324</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective. To determine the efficacy of tacrolimus ointment 0.1% on resistant cutaneous lesions in patients with lupus erythematosus. Methods. Twelve patients with skin manifestations were studied. Six had discoid lupus (DL), four subacute cutaneous lupus erythematosus (SCLE) and two systemic lupus erythematosus (SLE). All patients had extensive skin lesions refractory to previous treatment. Patients received topical tacrolimus 0.1% for a minimum of 6 weeks and response was evaluated by physicians’ and patients’ assessment and documented with photographs at baseline and at the end of the treatment. Results. Eleven of 12 patients completed the therapy. One patient with DL discontinued because of side-effects—peeling and a burning sensation. Six patients were clearly improved, one patient had a minor remission of his face lesion while in four the rashes remained the same. Two patients with SCLE had significant regression of their lesions while the other two had no improvement. In DL, two had certain improvement, one minor improvement and two were without response. The patients with SLE had significant amelioration of their extensive photosensitive rash. Conclusion. Tacrolimus ointment 0.1% may be an effective alternative in patients with severe resistant cutaneous manifestations in lupus erythematosus.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Lampropoulos, C E" sort="Lampropoulos, C E" uniqKey="Lampropoulos C" first="C. E." last="Lampropoulos">C. E. Lampropoulos</name></region><name sortKey="D Cruz, D P" sort="D Cruz, D P" uniqKey="D Cruz D" first="D. P." last="D'Cruz">D. P. D'Cruz</name><name sortKey="Harrison, P" sort="Harrison, P" uniqKey="Harrison P" first="P." last="Harrison">P. Harrison</name><name sortKey="Hughes, G R V" sort="Hughes, G R V" uniqKey="Hughes G" first="G. R. V." last="Hughes">G. R. V. Hughes</name><name sortKey="Sangle, S" sort="Sangle, S" uniqKey="Sangle S" first="S." last="Sangle">S. Sangle</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F38 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001F38 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:1F92CFBC5790A24478CCF45C2340510AD4B2C4B2
|texte= Topical tacrolimus therapy of resistant cutaneous lesions in lupus erythematosus: a possible alternative
}}
| This area was generated with Dilib version V0.6.33. |  |